Cytotoxic compounds from Viscum coloratum (Kom.) Nakai

Bo Wen; Juan Pan; Xin Meng; Zhi-Chao Hao; Wei Guan; Hai-Xue Kuang; Qing-Shan Chen; Li-Li Zhang; Yan Liu; Bing-You Yang

doi:10.1515/znc-2023-0170

Cytotoxic compounds from Viscum coloratum (Kom.) Nakai

Z Naturforsch C J Biosci. 2024 Nov 14. doi: 10.1515/znc-2023-0170. Online ahead of print.

Authors

Bo Wen^{1

2}, Juan Pan^{1

2}, Xin Meng^{1

2}, Zhi-Chao Hao^{1

2}, Wei Guan^{1

2}, Hai-Xue Kuang^{1

2}, Qing-Shan Chen³, Li-Li Zhang³, Yan Liu^{1

2}, Bing-You Yang^{1

2}

Affiliations

¹ Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, China.
² Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First-Class Construction Interdiscipline), Harbin, China.
³ College of Agriculture, Northeast Agricultural University, Harbin 150030, China.

PMID: 39533781
DOI: 10.1515/znc-2023-0170

Abstract

Two new compounds (1-2) and a new artificial product (3) together with fifteen known compounds (4-18) were isolated from Viscum coloratum (Kom.) Nakai. Their structures were established by analysis of their spectroscopic data including MS, 1D and 2D NMR spectra, and comparison with existing literature. All the compounds were assessed for their cytotoxic activity against 4T1 and LN229 cells (with cisplatin as the positive control), and the anti-LN229 cytotoxicity of compounds 3, 4 and 5 were greater than that of 4T1 cells.

Keywords: Viscum coloratum (Kom.) Nakai; cytotoxicity; diarylheptanoids; flavonoids.