Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs

Popat Mohite; Shruti Sule; Anil Pawar; Hanan M Alharbi; Swastika Maitra; Vetriselvan Subramaniyan; Vinoth Kumarasamy; Daniel Ejim Uti; Celestine O Ogbu; Simon Inedu Oodo; Ajoy Kumer; Ayodeji Oluwafemi Idowu; Okechukwu N N Okoye

doi:10.1038/s41598-024-73760-7

Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs

Sci Rep. 2024 Nov 12;14(1):27724. doi: 10.1038/s41598-024-73760-7.

Authors

Affiliations

¹ AETs St. John Institute of Pharmacy and Research, Manor Road, Palghar, Maharashtra, India.
² MES's College of Pharmacy, Sonai, Tal- Newasa, Ahmednagar, Maharashtra, India.
³ Department of Pharmaceutical Sciences, College of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia.
⁴ Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
⁵ Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, 10032, USA.
⁶ Department of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur, 56000, Malaysia.
⁷ Department of Research Publications, Kampala International University, Main Campus, P. O. Box 20000, Kampala, Uganda. daniel.ejimuti@kiu.ac.ug.
⁸ Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Federal University of Health Sciences, Otukpo, Benue State, Nigeria. daniel.ejimuti@kiu.ac.ug.
⁹ Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Federal University of Health Sciences, Otukpo, Benue State, Nigeria.
¹⁰ Chemistry, IUBAT-International University of Business Agriculture & Technology, Dhaka, Bangladesh.
¹¹ Centre for Excellence in Functional foods and Gastronomy Faculty of Agro-industry, Prince of Songkla University, Hat Yai, Thailand.
¹² Department of Industrial Chemistry, College of Science, Evangel University Akaeze, Ebonyi, Nigeria.

^# Contributed equally.

Abstract

This study aimed to investigate the in vitro performance of self-nanoemulsifying drug delivery systems (SNEDDSs) of Ornidazole (ORD), a poorly water-soluble drug. Self-nanoemulsifying drug delivery systems of ORD were prepared using various oils, non-ionic surfactants, and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of ORD in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading. The in vitro dissolution of SNEDDS was studied to compare the solubility of the representative formulations with API. The results from the characterization and solubility studies showed that SNEDDS formulations were stable with lower droplet sizes and showed higher ORD solubility. From the dissolution studies, it was found that the developed A7-SNEDDS formulation provided a significantly higher rate of ORD release (98.94 ± 0.68 in 1.0 h) compared to API. ORD-loaded SNEDDS formulations could be a potential oral pharmaceutical product with high drug-loading capacity, improved drug dissolution, and enhanced oral bioavailability.

Keywords: Cosurfactant, solubility; Ornidazole self-nano emulsifying system; Surfactant.

MeSH terms

Administration, Oral
Biological Availability*
Drug Delivery Systems
Drug Liberation
Emulsions* / chemistry
Nanoparticle Drug Delivery System / chemistry
Nanoparticles / chemistry
Ornidazole* / administration & dosage
Ornidazole* / chemistry
Ornidazole* / pharmacokinetics
Particle Size
Solubility*
Surface-Active Agents / chemistry

Substances

Ornidazole
Emulsions
Surface-Active Agents
Nanoparticle Drug Delivery System