Reports of tropane alkaloid poisonings and analytical techniques for their determination in food crops and products from 2013 to 2023

Compr Rev Food Sci Food Saf. 2024 Nov;23(6):e70047. doi: 10.1111/1541-4337.70047.

Abstract

Food safety is crucial to attaining food security and sustainability. Unsafe foods for human and animal consumption lead to product recalls and rejection, negatively impacting the global economy and trade. Similarly, climate change can adversely affect the availability of safe and nutritious food at the table. The changing climatic conditions and global food trade and transport can make the movement of toxic plants possible, resulting in food crops being increasingly invaded by some species of plants that produce toxic secondary metabolites, such as tropane alkaloids (TAs). Datura stramonium from the Solanaceae plant family is an invasive and virulent plant that produces high amounts of two TAs, atropine and scopolamine. Various food poisoning events following accidental or deliberate ingestion of foods contaminated by atropine and scopolamine from seeds of D. stramonium have been recorded in different locations globally. Due to these incidents, regulatory agencies require the development of plant toxin detection methods that can be used in the food chain as early as possible. This systematic review thus focuses on the TA determination techniques in food and feeds published between 2013 and 2023. A particular focus was given to the sample preparation methods, the improvements of each technique claimed, and data to support the performance of each method, especially the ability to measure at or below the maximum level. The review concludes with other technological advancements, including rapid spectroscopy, electrophoresis, and colorimetric methods, as well as the possibility of coupling with smartphones for use in on-farm detection and the challenges in applying them.

Keywords: chromatography; immunoassays; scopolamine; spectroscopy; tropane alkaloids.

Publication types

  • Systematic Review
  • Review

MeSH terms

  • Alkaloids / analysis
  • Alkaloids / chemistry
  • Crops, Agricultural* / chemistry
  • Datura stramonium / chemistry
  • Food Contamination / analysis
  • Foodborne Diseases / etiology
  • Foodborne Diseases / prevention & control
  • Humans
  • Tropanes* / analysis

Substances

  • Tropanes
  • Alkaloids