Positron Emission Tomography (PET) is a crucial imaging modality in oncology, providing functional insights by detecting metabolic activity in tissues. Total-body (TB) PET and large field-of-view PET have emerged as advanced techniques, offering whole-body imaging in a single acquisition. TB PET enables simultaneous imaging from head to toe, providing comprehensive information on tumor distribution, metastasis, and treatment response. This is particularly valuable in oncology, where metastatic spread often requires evaluation of multiple body areas. By covering the entire body, TB PET improves diagnostic accuracy, reduces scan time, and increases patient comfort. Furthermore, these new tomographs offer a marked increase in sensitivity, thanks to their ability to capture a larger volume of data simultaneously. This heightened sensitivity enables the detection of smaller lesions and more subtle metabolic changes, improving diagnostic accuracy in the early stages of cancer or in the evaluation of minimal residual disease. Moreover, the increased sensitivity allows for lower radiotracer doses without compromising image quality, reducing patient exposure to radiation or very quick acquisitions. Another significant advantage is the possibility of dynamic acquisitions, which allow for continuous monitoring of tracer kinetics over time. This provides critical information about tissue perfusion, metabolism, and receptor binding in real time. Dynamic imaging is particularly useful for assessing treatment response in oncology, as it enables the evaluation of tumor behavior over a period rather than a single static snapshot, offering insights into tumor aggressiveness and potential therapeutic targets. This review is focused on the current applications of TB and large field-of-view PET scanners in oncology.
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