Trained immunity in the bone marrow: Hub of autoimmunity

Mihai G Netea; Leo A B Joosten

doi:10.1016/j.stem.2024.10.008

Trained immunity in the bone marrow: Hub of autoimmunity

Cell Stem Cell. 2024 Nov 7;31(11):1555-1557. doi: 10.1016/j.stem.2024.10.008.

Authors

Mihai G Netea¹, Leo A B Joosten²

Affiliations

¹ Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands; Department for Immunology and Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany. Electronic address: mihai.netea@radboudumc.nl.
² Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

PMID: 39515297
DOI: 10.1016/j.stem.2024.10.008

Abstract

An inappropriate induction of trained immunity in the bone marrow progenitors of immune cells has been described to underlie chronic inflammatory processes. Mills and colleagues' recently published paper in Cell Stem Cell shows that maladaptive trained immunity drives inflammation in autoimmune processes,¹ opening a new area of research in autoimmunity.

MeSH terms

Animals
Autoimmunity* / immunology
Bone Marrow Cells / immunology
Bone Marrow* / immunology
Bone Marrow* / pathology
Humans
Inflammation / immunology
Inflammation / pathology
Trained Immunity