Microbiota and cognitive impairment: Current challenges and future perspectives

J Alzheimers Dis. 2024 Nov;102(2):311-313. doi: 10.1177/13872877241289057. Epub 2024 Nov 3.

Abstract

Recent studies indicate that gut microbiota may play a crucial role in cognitive function. Individuals with cognitive impairment tend to have fewer beneficial gut bacteria and lower microbial diversity. Therefore, gut microbiota could be a potential biomarker for cognitive vulnerability. Further research is needed to understand the mechanisms and lifestyle factors affecting both microbiota composition and cognitive health. While the direct impact of microbiota and diet on cognitive impairment remains unconfirmed, this area holds promise for developing new preventive and treatment strategies.

Keywords: Alzheimer's disease; aging; biomarker; dementia; frailty; microbiota; neurocognitive disease; nutrition; older patient; short chain fatty acid.

Publication types

  • Review

MeSH terms

  • Cognitive Dysfunction* / microbiology
  • Gastrointestinal Microbiome* / physiology
  • Humans