A BODIPY derivative for PDT/PTT synergistic treatment of bacterial infections

J Photochem Photobiol B. 2024 Dec:261:113049. doi: 10.1016/j.jphotobiol.2024.113049. Epub 2024 Oct 28.

Abstract

Phototherapeutic antimicrobials, including photodynamic and photothermal antimicrobials, are considered effective alternatives for antibiotic strategy due to their broad-spectrum antibacterial activity and low risk of resistance. Here, a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivative containing triphenylamine groups was co-assembled with Pluronic F-127 (F-127) to form nanoparticles (BICF NPs). BICF NPs have excellent photodynamic and photothermal properties and are demonstrated to be effective in inhibiting and disrupting bacterial biofilms, thereby promoting the healing of subcutaneous abscesses. This work provides a new avenue for antibiotic replacement therapy.

Keywords: Abscess; Antimicrobial agent; BODIPY; Photodynamic therapy; Photothermal therapy.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Infections / drug therapy
  • Biofilms* / drug effects
  • Boron Compounds* / chemistry
  • Boron Compounds* / pharmacology
  • Boron Compounds* / therapeutic use
  • Mice
  • Nanoparticles* / chemistry
  • Nanoparticles* / therapeutic use
  • Photochemotherapy*
  • Photosensitizing Agents* / chemistry
  • Photosensitizing Agents* / pharmacology
  • Photosensitizing Agents* / therapeutic use
  • Poloxamer / chemistry
  • Staphylococcus aureus / drug effects

Substances

  • Boron Compounds
  • 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
  • Photosensitizing Agents
  • Anti-Bacterial Agents
  • Poloxamer