Sarcopenia in patients receiving TIPS is independently associated with increased risk of complications and mortality

Emma Vanderschueren; Philippe Meersseman; Alexander Wilmer; Vincent Vandecaveye; Evelyne Dubois; Anne Van Eldere; Jan Clerick; Jo P Peluso; Eveline Claus; Lawrence Bonne; Chris Verslype; Geert Maleux; Wim Laleman

doi:10.1016/j.dld.2024.10.013

Sarcopenia in patients receiving TIPS is independently associated with increased risk of complications and mortality

Dig Liver Dis. 2024 Oct 28:S1590-8658(24)01056-9. doi: 10.1016/j.dld.2024.10.013. Online ahead of print.

Authors

Affiliations

¹ Department of Gastroenterology and Hepatology, University Hospital Leuven, Herestraat 49, Leuven, Belgium; Department of Chronic Diseases, Metabolism and Aging (CHROMETA), Catholic University of Leuven, Herestraat 49, Leuven, Belgium. Electronic address: emma.vanderschueren@uzleuven.be.
² Department of General Internal Medicine, Medical Intensive Care Unit, University Hospital Leuven, Herestraat 49, Leuven, Belgium.
³ Department of Radiology, Abdominal Radiology, University Hospital Leuven, Herestraat 49, Leuven, Belgium.
⁴ Department of Gastroenterology and Hepatology, University Hospital Leuven, Herestraat 49, Leuven, Belgium.
⁵ Department of Radiology, Interventional Radiology, University Hospital Leuven, Herestraat 49, Leuven, Belgium.
⁶ Department of Gastroenterology and Hepatology, University Hospital Leuven, Herestraat 49, Leuven, Belgium; Department of Chronic Diseases, Metabolism and Aging (CHROMETA), Catholic University of Leuven, Herestraat 49, Leuven, Belgium.

PMID: 39472174
DOI: 10.1016/j.dld.2024.10.013

Abstract

Background: Sarcopenia is an acknowledged risk factor for individuals with chronic liver disease, however, the influence on outcomes in patients receiving transjugular intrahepatic portosystemic shunt (TIPS) remains underexplored.

Aims: This study aimed to investigate the association between sarcopenia and incidence of complications and mortality post-TIPS.

Methods: A retrospective analysis was performed on 175 patients who underwent TIPS between 2011-2021 at a Belgian tertiary care center. Transverse psoas muscle thickness (TPMT) was measured at baseline, with a subset of 85 patients having a second TPMT after 1-2 years for assessment of evolution.

Results: Over a median follow-up of 453 days (IQR 76-1179), sarcopenic patients exhibited a higher prevalence of complications (74.1% vs. 57.9%, p = 0.04) and one-year mortality (53.4% vs. 22.3%, p < 0.001) post-TIPS. Notably, 58.8% of patients showed an increase >10% from baseline TPMT/length post-TIPS, with the greatest improvement observed in severely sarcopenic patients (4.00 ± 4.55 mm/m vs. -0.82 ± 2.68 mm/m, p < 0.001) and in those patients free from TIPS-related complications (3.18 ± 4.09 mm/m vs. 1.31 ± 3.21 mm/m, p = 0.022).

Conclusion: Sarcopenia increases the risk of complications and mortality post-TIPS. Importantly, sarcopenia improves in patients receiving TIPS, particularly in those with severe sarcopenia at baseline and free of TIPS-related complications.

Keywords: Complications; Dysfunction; Portosystemic shunt; Sarcopenia.