Review of the Effects of Antiviral Therapy on Hepatitis B/C-Related Mortality and the Regression of Fibrosis

Stephen Sinclair 3rd; Sean Shearen; Youssef Ghobrial; George Trad; Syed Abdul Basit; David Shih; John K Ryan

doi:10.3390/v16101531

Review of the Effects of Antiviral Therapy on Hepatitis B/C-Related Mortality and the Regression of Fibrosis

Viruses. 2024 Sep 27;16(10):1531. doi: 10.3390/v16101531.

Authors

Stephen Sinclair 3rd¹, Sean Shearen¹, Youssef Ghobrial¹, George Trad¹, Syed Abdul Basit¹, David Shih¹, John K Ryan¹

Affiliation

¹ Comprehensive Digestive Institute of Nevada, Las Vegas, NV 89148, USA.

Abstract

Hepatitis B and Hepatitis C are viral causes of Hepatitis that lead to significant worldwide mortality and morbidity through the sequelae of fibrosis and hepatocellular carcinoma. In this review, we have summarized recent studies that have examined the effects of antiviral therapy on the regression of fibrosis and the reduction in mortalities associated with the viruses. Antiviral therapy significantly decreases mortality and induces the regression of fibrosis.

Keywords: HBV; HCV; Hepatitis B; Hepatitis C; cirrhosis; decompensated cirrhosis; fibrosis; liver-related mortality; portal hypertension; viral Hepatitis.

Publication types

Review

MeSH terms

Antiviral Agents* / therapeutic use
Hepacivirus / drug effects
Hepatitis B virus / drug effects
Hepatitis B virus / physiology
Hepatitis B* / complications
Hepatitis B* / drug therapy
Hepatitis B* / mortality
Hepatitis B* / virology
Hepatitis B, Chronic / complications
Hepatitis B, Chronic / drug therapy
Hepatitis B, Chronic / mortality
Hepatitis B, Chronic / virology
Hepatitis C / complications
Hepatitis C / drug therapy
Hepatitis C / mortality
Hepatitis C / virology
Humans
Liver Cirrhosis* / drug therapy
Liver Cirrhosis* / mortality
Liver Cirrhosis* / virology

Substances

Antiviral Agents

Grants and funding

This research received no external funding.