Acute Effects of Taurine Supplementation on Maximal Fat Oxidation and FATmax in Recreational Endurance Runners: A Randomized, Placebo-Controlled, Crossover, and Triple-Blinded Study

Int J Sport Nutr Exerc Metab. 2024 Nov 19;35(1):3-11. doi: 10.1123/ijsnem.2024-0076. Print 2025 Jan 1.

Abstract

Taurine (TAU) has been shown to improve time to exhaustion (TTE) and fat oxidation during exercise; however, no studies have examined the effect of acute TAU supplementation on maximal fat oxidation (MFO) and related intensity to MFO (FATmax). Our study aimed to investigate the effect of acute TAU supplementation on MFO, FATmax, VO2peak, and TTE. Eleven recreationally trained male endurance runners performed three incremental running tests. The first visit included a familiarization to the test, followed by two subsequent visits in which exercise was performed 90 min after ingestion of either 6-g TAU or placebo (PLA) using a triple-blind randomized crossover design. There was no effect of TAU on MFO (p = .89, d = -0.07, TAU: 0.48 ± 0.22 g/min; PLA: 0.49 ± 0.15 g/min or FATmax (p = .26, d = -0.66; TAU: 49.17 ± 15.86 %V˙O2peak; PLA: 56.00 ± 13.27 %V˙O2peak). TTE was not significantly altered (TAU: 1,444.8 ± 88.6 s; PLA: 1,447.6 ± 87.34 s; p = .65, d = -0.04). TAU did not show any effect on V˙O2peak in comparison with PLA (TAU: 58.9 ± 8.4 ml·kg-1·min-1; PLA: 56.5 ± 5.7 ml·kg-1·min-1, p = .47, d = 0.48). However, V˙O2 was increased with TAU at most stages of exercise with large effect sizes. The acute ingestion of 6 g of TAU before exercise did not enhance MFO, FATmax, or TTE. However, it did increase the oxygen cost of running fixed intensities in recreationally trained endurance runners.

Keywords: endurance running; incremental test; metabolic flexibility; oxygen uptake; time to exhaustion.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Cross-Over Studies
  • Dietary Supplements*
  • Humans
  • Lipid Metabolism / drug effects
  • Male
  • Oxidation-Reduction*
  • Oxygen Consumption*
  • Physical Endurance* / drug effects
  • Physical Endurance* / physiology
  • Running* / physiology
  • Sports Nutritional Physiological Phenomena
  • Taurine* / administration & dosage
  • Taurine* / pharmacology
  • Young Adult

Substances

  • Taurine