Organ-on-chip technology: Opportunities and challenges

Santosh Kumar Srivastava; Guo Wei Foo; Nikhil Aggarwal; Matthew Wook Chang

doi:10.1016/j.biotno.2024.01.001

Organ-on-chip technology: Opportunities and challenges

Biotechnol Notes. 2024 Jan 5:5:8-12. doi: 10.1016/j.biotno.2024.01.001. eCollection 2024.

Authors

Santosh Kumar Srivastava^{1

2

3}, Guo Wei Foo^{1

2

4

3}, Nikhil Aggarwal^{1

2

3}, Matthew Wook Chang^{1

2

4

3}

Affiliations

¹ NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore.
² Synthetic Biology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
³ National Centre for Engineering Biology (NCEB), Singapore.
⁴ Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Abstract

Organ-on-chip (OOC) technology is an innovative approach that reproduces human organ structures and functions on microfluidic platforms, offering detailed insights into intricate physiological processes. This technology provides unique advantages over conventional in vitro and in vivo models and thus has the potential to become the new standard for biomedical research and drug screening. In this mini-review, we compare OOCs with conventional models, highlighting their differences, and present several applications of OOCs in biomedical research. Additionally, we highlight advancements in OOC technology, particularly in developing multiorgan systems, and discuss the challenges and future directions of this field.

Keywords: 2D/3D culture models; Gut-on-Chip; Kidney-on-chip; Liver-on-chip; Lung-on-chip; Microfluidics; Organs-on-chips (OOCs).

Publication types

Review