Dipolar-hollowed α-Fe2O3@Au/Polydopamine nanospindle for photothermal-photodynamic coupling antibacterial and drug-delivery

Guangjin Yu; Jing Wang; Qingshan Xiong; Yunqi Xu; Shouhu Xuan; Ken Cham-Fai Leung; Qunling Fang

doi:10.1016/j.ijbiomac.2024.136615

Dipolar-hollowed α-Fe₂O₃@Au/Polydopamine nanospindle for photothermal-photodynamic coupling antibacterial and drug-delivery

Int J Biol Macromol. 2024 Oct 14:136615. doi: 10.1016/j.ijbiomac.2024.136615. Online ahead of print.

Authors

Guangjin Yu¹, Jing Wang², Qingshan Xiong³, Yunqi Xu⁴, Shouhu Xuan⁵, Ken Cham-Fai Leung⁶, Qunling Fang⁷

Affiliations

¹ Department of Chirurgery, Affiliated Hospital 1, Anhui Medical University, Hefei 230032, PR China; Department of Hepatobiliary Surgery, Dongcheng branch of the First Affiliated Hospital of Anhui Medical University (Feidong People's Hospital), Hefei 230027, PR China.
² School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, PR China; Institute of Plasma Physics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, PR China.
³ School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, PR China.
⁴ CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China, Hefei 230027, PR China.
⁵ CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China, Hefei 230027, PR China; Anhui Provincial Key Laboratory of Aerosol Analysis, Regulation and Biological Effect, Hefei 230000, PR China. Electronic address: xuansh@ustc.edu.cn.
⁶ State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, The Hong Kong Baptist University, Kowloon, Hong Kong. Electronic address: cfleung@hkbu.edu.hk.
⁷ School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, PR China. Electronic address: fql.good@hfut.edu.cn.

PMID: 39414200
DOI: 10.1016/j.ijbiomac.2024.136615

Abstract

With the prevalence of drug-resistant bacteria and the waning effects of antibiotics, nanoplatform has become an effective strategy for fighting infections. This work reports a dipolar-hollowed α-Fe₂O₃@Au/Polydopamine (PDA) nanospindle which possesses both photothermal-photodynamic (PTT-PDT) coupling antibacterial and drug carrying performance. Firstly, the spindle type α-Fe₂O₃@Au/PDA particle was prepared by a simple one-step strategy and then the dipolar-hollow structure was obtained by controlling etching the inside α-Fe₂O₃ core with hydrochloric acid. After further loading the photosensitizer zinc phthalocyanine (ZnPc), the dipolar-hollowed α-Fe₂O₃@Au/PDA-ZnPc nanospindles were obtained. Owing to the dipolar-hollowed interior, the nanospindles are also effective in carrying antitumor drug doxorubicin (DOX) and shows a good drug loading-release behavior. The dipolar-hollowed α-Fe₂O₃@Au/PDA nanospindles exhibits a high antibacterial performance against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) under near-infrared (NIR) and Xenon lamp irradiation. When α-Fe₂O₃@Au/PDA-ZnPc nanospindles concentration was increased to 100 μg/mL, the antibacterial rate was close to 100 %. In comparison to the original α-Fe₂O₃@Au/PDA nanospindles, the product achieved a lower effective antibacterial temperature. This triple-mode therapy (PTT/PDT/Drug) provides an interesting design idea for anisotropic therapeutic nanoplatform which can be applied in low-temperature antibacterial and drug delivery.

Keywords: Anisotropic; Antibacterial; Drug delivery; Photodynamic; Photothermal.