The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters

Sci Signal. 2024 Oct 15;17(858):eadn6324. doi: 10.1126/scisignal.adn6324. Epub 2024 Oct 15.

Abstract

Cytokines induce functional and metabolic adaptations in immune cells, typically through transcriptional responses that can be influenced by other extracellular signals and by intracellular factors. The binding of the cytokine interleukin-4 (IL-4) to its receptor induces the phosphorylation and activation of the transcription factor STAT6. The aryl hydrocarbon receptor (AhR), a transcription factor activated by various endogenous and microbe-derived metabolites, modulates the responses of immune cells to danger signals or inflammatory mediators such as cytokines. Here, we investigated cross-talk between the AhR and signaling stimulated by IL-4 in human and mouse monocytes. AhR activation was required for a subset of IL-4-induced transcriptional responses and inhibited the IL-4-induced metabolic switch to fatty acid β-oxidation. The promoters of the genes that were induced by IL-4 in an AhR-dependent manner lacked canonical AhR binding sites, implying a nongenomic mechanism of AhR action. Mechanistically, AhR activation reduced the activity of SHP-1, a phosphatase that targets and inhibits STAT6, and prolonged STAT6 phosphorylation and binding to specific target loci, thus extending the duration of STAT6 activity. Our results identify AhR as a key player in the molecular control of responses to IL-4 in monocytes and suggest a nongenomic mechanism through which AhR ligands may influence the functional responses of cells to IL-4.

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • Humans
  • Interleukin-4* / genetics
  • Interleukin-4* / metabolism
  • Interleukin-4* / pharmacology
  • Mice
  • Mice, Inbred C57BL
  • Monocytes* / metabolism
  • Phosphorylation
  • Promoter Regions, Genetic*
  • Protein Binding
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6 / genetics
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6 / metabolism
  • Receptors, Aryl Hydrocarbon* / genetics
  • Receptors, Aryl Hydrocarbon* / metabolism
  • STAT6 Transcription Factor* / genetics
  • STAT6 Transcription Factor* / metabolism
  • Signal Transduction
  • Transcription, Genetic

Substances

  • Receptors, Aryl Hydrocarbon
  • STAT6 Transcription Factor
  • Interleukin-4
  • STAT6 protein, human
  • Stat6 protein, mouse
  • AHR protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • IL4 protein, human
  • Basic Helix-Loop-Helix Transcription Factors