Photochemical alkylation of quinoxalin-2(1 H)-ones with N, N, N', N'-tetraalkylethylenediamine

Yaqing Zhu; Yi Zhang; Xia Zhao; Kui Lu

doi:10.1039/d4ob01494d

Photochemical alkylation of quinoxalin-2(1 H)-ones with N, N, N', N'-tetraalkylethylenediamine

Org Biomol Chem. 2024 Nov 21;22(45):8951-8957. doi: 10.1039/d4ob01494d.

Authors

Yaqing Zhu¹, Yi Zhang¹, Xia Zhao², Kui Lu¹

Affiliations

¹ China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, TianJin University of Science &Technology, TianJin 300457, China. lukui@tust.edu.cn.
² College of Chemistry, TianJin Key Laboratory of Structure and Performance for Functional Molecules, TianJin Normal University, TianJin, 300387, China.

PMID: 39405168
DOI: 10.1039/d4ob01494d

Abstract

A visible-light-induced C-3 alkylation of quinoxalin-2(1H)-ones with N,N,N',N'-tetraalkylethylenediamine was achieved without an external photocatalyst. The mechanism showed that quinoxalin-2(1H)-ones could act as photocatalysts. The accessibility of the reagents and the green and mild reaction conditions made this protocol an alternative method to access C-3 alkylated quinoxalin-2(1H)-ones.