Pathophysiology of Peritoneal Metastasis

Jesse Demuytere; Sam Ernst; Wim Ceelen

doi:10.1002/jso.27890

Pathophysiology of Peritoneal Metastasis

J Surg Oncol. 2024 Oct 13. doi: 10.1002/jso.27890. Online ahead of print.

Authors

Jesse Demuytere^{1

2}, Sam Ernst^{1

2

3}, Wim Ceelen^{1

2}

Affiliations

¹ Experimental Surgery Lab, Ghent University, Ghent, Belgium.
² Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
³ Laboratory of Experimental Cancer Research (LECR), Ghent University, Ghent, Belgium.

PMID: 39400354
DOI: 10.1002/jso.27890

Abstract

Peritoneal metastasis is the result of a complex, stepwise process that involves multiple, spatially and temporally distinct interactions between the primary cancer, disseminated cancer cells or clusters, and the mesothelial lining of the peritoneal cavity and intraperitoneal organs. The biology of peritoneal metastasis, long a neglected field of research, is now increasingly being unraveled. Here, we provide an update on the mechanisms that drive the journey that eventually leads to widespread peritoneal metastatic disease.

Keywords: metastasis; pathophysiology; peritoneal.

Publication types

Review