Kikuchi-Fujimoto Disease Presenting as Autoimmune Limbic Encephalitis: A Case Report with Review of Literature

S B Punith; Ayush Agarwal; Divyani Garg; Ajay Garg; Shamim A Shamim; Saumya Ranjan Mallick; Pranjal Gupta; Achal K Srivastava

doi:10.4103/aian.aian_498_24

Kikuchi-Fujimoto Disease Presenting as Autoimmune Limbic Encephalitis: A Case Report with Review of Literature

Ann Indian Acad Neurol. 2024 Oct 8. doi: 10.4103/aian.aian_498_24. Online ahead of print.

Authors

S B Punith¹, Ayush Agarwal¹, Divyani Garg¹, Ajay Garg², Shamim A Shamim³, Saumya Ranjan Mallick⁴, Pranjal Gupta⁵, Achal K Srivastava¹

Affiliations

¹ Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
² Department of Neuroimaging and Interventional Neuroradiology, All India Institute of Medical Sciences, New Delhi, India.
³ Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
⁴ Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
⁵ Department of Neurology, Wayne State University, Detroit, Michigan, USA.

PMID: 39377240
DOI: 10.4103/aian.aian_498_24

Abstract

Kikuchi-Fujimoto disease (KFD) is a rare benign condition associated with fever and lymphadenopathy and was first described by Kikuchi and Fujimoto independently in 1972 as histiocytic necrotizing lymphadenitis. The diagnosis is made by histopathology with immunohistochemistry. Limbic encephalitis is an extremely rare presentation of this uncommon disease, which has been described mainly in children. Available evidence is sparse in the form of case reports and case series in the form of 10 cases published till date. We report a case of an adult female with KFD with autoimmune limbic encephalitis, who had complete clinical and radiologic recovery with treatment, and a literature review of all the cases published till date.