Molecular mechanisms regulating T helper 2 cell differentiation and function

Abstract

T helper 2 (T_H2) cells orchestrate type 2 immunity during protective antihelminth immunity and help restore tissue homoeostasis. Their misdirected activities against innocuous substances also underlie atopic diseases, such as asthma and allergy. Recent technological advances are uncovering novel insights into the molecular mechanisms governing T_H2 cell differentiation and function.