Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol

Douglas C Dean 3rd; M Dylan Tisdall; Jessica L Wisnowski; Eric Feczko; Borjan Gagoski; Andrew L Alexander; Richard A E Edden; Wei Gao; Timothy J Hendrickson; Brittany R Howell; Hao Huang; Kathryn L Humphreys; Tracy Riggins; Chad M Sylvester; Kimberly B Weldon; Essa Yacoub; Banu Ahtam; Natacha Beck; Suchandrima Banerjee; Sergiy Boroday; Arvind Caprihan; Bryan Caron; Samuel Carpenter; Yulin Chang; Ai Wern Chung; Matthew Cieslak; William T Clarke; Anders Dale; Samir Das; Christopher W Davies-Jenkins; Alexander J Dufford; Alan C Evans; Laetitia Fesselier; Sandeep K Ganji; Guillaume Gilbert; Alice M Graham; Aaron T Gudmundson; Maren Macgregor-Hannah; Michael P Harms; Tom Hilbert; Steve C N Hui; M Okan Irfanoglu; Steven Kecskemeti; Tobias Kober; Joshua M Kuperman; Bidhan Lamichhane; Bennett A Landman; Xavier Lecour-Bourcher; Erik G Lee; Xu Li; Leigh MacIntyre; Cecile Madjar; Mary Kate Manhard; Andrew R Mayer; Kahini Mehta; Lucille A Moore; Saipavitra Murali-Manohar; Cristian Navarro; Mary Beth Nebel; Sharlene D Newman; Allen T Newton; Ralph Noeske; Elizabeth S Norton; Georg Oeltzschner; Regis Ongaro-Carcy; Xiawei Ou; Minhui Ouyang; Todd B Parrish; James J Pekar; Thomas Pengo; Carlo Pierpaoli; Russell A Poldrack; Vidya Rajagopalan; Dan W Rettmann; Pierre Rioux; Jens T Rosenberg; Taylor Salo; Theodore D Satterthwaite; Lisa S Scott; Eunkyung Shin; Gizeaddis Simegn; W Kyle Simmons; Yulu Song; Barry J Tikalsky; Jean Tkach; Peter C M van Zijl; Jennifer Vannest; Maarten Versluis; Yansong Zhao; Helge J Zöllner; Damien A Fair; Christopher D Smyser; Jed T Elison; HBCD MRI Working Group

doi:10.1016/j.dcn.2024.101452

Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol

Dev Cogn Neurosci. 2024 Sep 21:70:101452. doi: 10.1016/j.dcn.2024.101452. Online ahead of print.

Authors

Douglas C Dean 3rd¹, M Dylan Tisdall², Jessica L Wisnowski³, Eric Feczko⁴, Borjan Gagoski⁵, Andrew L Alexander⁶, Richard A E Edden⁷, Wei Gao⁸, Timothy J Hendrickson⁹, Brittany R Howell¹⁰, Hao Huang¹¹, Kathryn L Humphreys¹², Tracy Riggins¹³, Chad M Sylvester¹⁴, Kimberly B Weldon¹⁵, Essa Yacoub¹⁶, Banu Ahtam¹⁷, Natacha Beck¹⁸, Suchandrima Banerjee¹⁹, Sergiy Boroday¹⁸, Arvind Caprihan²⁰, Bryan Caron¹⁸, Samuel Carpenter²¹, Yulin Chang²², Ai Wern Chung¹⁷, Matthew Cieslak²³, William T Clarke²⁴, Anders Dale²⁵, Samir Das¹⁸, Christopher W Davies-Jenkins⁷, Alexander J Dufford²⁶, Alan C Evans¹⁸, Laetitia Fesselier¹⁸, Sandeep K Ganji²⁷, Guillaume Gilbert²⁸, Alice M Graham²¹, Aaron T Gudmundson⁷, Maren Macgregor-Hannah²⁹, Michael P Harms³⁰, Tom Hilbert³¹, Steve C N Hui³², M Okan Irfanoglu³³, Steven Kecskemeti³⁴, Tobias Kober³¹, Joshua M Kuperman³⁵, Bidhan Lamichhane³⁶, Bennett A Landman³⁷, Xavier Lecour-Bourcher¹⁸, Erik G Lee⁹, Xu Li⁷, Leigh MacIntyre³⁸, Cecile Madjar¹⁸, Mary Kate Manhard³⁹, Andrew R Mayer²⁰, Kahini Mehta²³, Lucille A Moore¹⁵, Saipavitra Murali-Manohar⁷, Cristian Navarro⁴⁰, Mary Beth Nebel⁴¹, Sharlene D Newman⁴², Allen T Newton⁴³, Ralph Noeske⁴⁴, Elizabeth S Norton⁴⁵, Georg Oeltzschner⁷, Regis Ongaro-Carcy¹⁸, Xiawei Ou⁴⁶, Minhui Ouyang¹¹, Todd B Parrish⁴⁷, James J Pekar⁷, Thomas Pengo²⁹, Carlo Pierpaoli³³, Russell A Poldrack⁴⁸, Vidya Rajagopalan³, Dan W Rettmann⁴⁹, Pierre Rioux¹⁸, Jens T Rosenberg⁵⁰, Taylor Salo²³, Theodore D Satterthwaite²³, Lisa S Scott⁵¹, Eunkyung Shin⁵², Gizeaddis Simegn⁷, W Kyle Simmons⁵³, Yulu Song⁷, Barry J Tikalsky¹⁵, Jean Tkach³⁹, Peter C M van Zijl⁷, Jennifer Vannest⁵⁴, Maarten Versluis²⁷, Yansong Zhao⁵⁵, Helge J Zöllner⁷, Damien A Fair⁵⁶, Christopher D Smyser⁵⁷, Jed T Elison⁵⁸; HBCD MRI Working Group

Affiliations

¹ Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: deaniii@wisc.edu.
² Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
³ Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Department of Radiology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
⁴ Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
⁵ Department of Radiology, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.
⁶ Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
⁷ Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
⁸ Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
⁹ Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA.
¹⁰ Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA; Department of Human Development and Family Science, Virginia Tech, Blacksburg, VA, USA.
¹¹ Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
¹² Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.
¹³ Department of Psychology, University of Maryland, College Park, MD, USA.
¹⁴ Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA; Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, St. Louis, MO, USA.
¹⁵ Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
¹⁶ Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
¹⁷ Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
¹⁸ McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
¹⁹ GE HealthCare, Menlo Park, CA, USA.
²⁰ The Mind Research Network, Albuquerque, NM, USA.
²¹ Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA.
²² Siemens Medical Solutions USA Inc, PA, USA.
²³ Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
²⁴ Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
²⁵ Department of Radiology, University of California San Diego, La Jolla, CA, USA; Multimodal Imaging Laboratory, University of California San Diego, La Jolla, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
²⁶ Department of Psychiatry and Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, USA.
²⁷ MR Clinical Science, Philips Healthcare, Best, the Netherlands.
²⁸ MR Clinical Science, Philips Healthcare, Mississauga, Ontario, Canada.
²⁹ Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA.
³⁰ Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
³¹ Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland,; Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland,; LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
³² Developing Brain Institute, Children's National Hospital, Washington, DC, USA; Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
³³ Quantitative Medical Imaging Laboratory, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.
³⁴ Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
³⁵ Department of Radiology, University of California San Diego, La Jolla, CA, USA.
³⁶ Center for Health Sciences, Oklahoma State University, Tulsa, OK, USA.
³⁷ Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.
³⁸ McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; Lasso Informatics, Canada.
³⁹ Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
⁴⁰ Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA.
⁴¹ Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
⁴² Alabama Life Research Institute, University of Alabama, Tuscaloosa, AL, USA; Department of Psychology, University of Alabama, Tuscaloosa, AL, USA.
⁴³ Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA; Monroe Carell Jr. Children's Hospital at Vandebrilt, Vanderbilt University Medical Center, Nashville, TN, USA.
⁴⁴ GE HealthCare, Munich, Germany.
⁴⁵ Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL, USA; Department of Medical Social Sciences, Feinberg School of Medicine, Chicago, IL, USA.
⁴⁶ Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
⁴⁷ Department of Radiology, Feinberg School of Medicine, Chicago, IL, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
⁴⁸ Department of Psychology, Stanford University, Stanford, CA, USA.
⁴⁹ GE HealthCare, Rochester, MN, USA.
⁵⁰ Advanced Magnetic Resonance Imaging and Spectroscopy Facility, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
⁵¹ Department of Psychology, University of Florida, Gainesville, FL, USA.
⁵² Department of Psychology, Pennsylvania State University, University Park, PA, USA.
⁵³ Department of Pharmacology and Physiology, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA; OSU Biomedical Imaging Center, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.
⁵⁴ Department of Communication Sciences and Disorders, University of Cincinnati, Cincinnati, OH, USA; Communication Sciences Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
⁵⁵ MR Clinical Science, Philips Healthcare, Cleveland, OH, USA.
⁵⁶ Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Institute of Child Development, University of Minnesota, Minneapolis, MN, USA. Electronic address: faird@umn.edu.
⁵⁷ Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA; Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: smyserc@wustl.edu.
⁵⁸ Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Institute of Child Development, University of Minnesota, Minneapolis, MN, USA. Electronic address: jtelison@umn.edu.

Abstract

The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The acquisition of multimodal magnetic resonance-based brain development data is central to the study's core protocol. However, application of Magnetic Resonance Imaging (MRI) methods in this population is complicated by technical challenges and difficulties of imaging in early life. Overcoming these challenges requires an innovative and harmonized approach, combining age-appropriate acquisition protocols together with specialized pediatric neuroimaging strategies. The HBCD MRI Working Group aimed to establish a core acquisition protocol for all 27 HBCD Study recruitment sites to measure brain structure, function, microstructure, and metabolites. Acquisition parameters of individual modalities have been matched across MRI scanner platforms for harmonized acquisitions and state-of-the-art technologies are employed to enable faster and motion-robust imaging. Here, we provide an overview of the HBCD MRI protocol, including decisions of individual modalities and preliminary data. The result will be an unparalleled resource for examining early neurodevelopment which enables the larger scientific community to assess normative trajectories from birth through childhood and to examine the genetic, biological, and environmental factors that help shape the developing brain.

Keywords: Development; HBCD; Infant; MRI; MRS; Protocol.