A 57-year-old black male patient was admitted with flatulence and post-prandial fullness a month ago. No other gastrointestinal complaints. He had history of arterial hypertension, medicated with nifedipine 30mg/day and hydrochlorthiazide 50mg/day, and had been diagnosed and treated for malaria a week before admission. The patient reported frequent bathing in rivers and smoking habits since the age of 18, around a pack and a half a day. Abdominal ultrasound showed periportal fibrosis, without findings of portal hypertension. A rectal biopsy was performed with findings of Schistosome mansoni eggs on microscopy. This case illustrates a patient who was admitted due to dyspeptic syndrome, and during the study of his condition was found to have periportal fibrosis, which in a country endemic for Schistosomiasis such as Mozambique, this pathology must always be investigated. A history of bathing in rivers increases the chances of it being Schistosomiasis, confirmed by the demonstration of parasite eggs in a rectal biopsy. Treatment with prazinquantel was done at a dose of 40 mg/kg and outpatient follow-up was scheduled for six months.