Revealing the gap: fractional exhaled nitric oxide and clinical responsiveness to biological therapy in severe asthma - a retrospective study

Mauro Maniscalco; Claudio Candia; Dina Visca; Maria D'Amato; Cecilia Calabrese; Pasquale Ambrosino; Antonio Molino; Salvatore Fuschillo

doi:10.1183/23120541.00296-2024

Revealing the gap: fractional exhaled nitric oxide and clinical responsiveness to biological therapy in severe asthma - a retrospective study

ERJ Open Res. 2024 Sep 23;10(5):00296-2024. doi: 10.1183/23120541.00296-2024. eCollection 2024 Sep.

Authors

Mauro Maniscalco^{1

2}, Claudio Candia², Dina Visca³, Maria D'Amato², Cecilia Calabrese⁴, Pasquale Ambrosino⁵, Antonio Molino², Salvatore Fuschillo¹

Affiliations

¹ Istituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme, Telese Terme, Italy.
² Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.
³ Istituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Tradate Institute, Telese Terme, Italy.
⁴ University of Campania "Luigi Vanvitelli", Naples, Italy.
⁵ Istituti Clinici Scientifici Maugeri IRCCS, Directorate of Telese Terme Institute, Telese Terme, Italy.

Abstract

A proportion of patients with severe asthma treated with biological drugs undergoes a significant decline in F _ENO. However, variations in F _ENO are largely independent of the clinical efficacy of the biological drug therapy. https://bit.ly/3xWszYJ.