Abdominal pain is one of the most common presenting complaints to the emergency department, and appendicitis and diverticulitis are common causes. Intra-abdominal infections have historically been managed with admission to the hospital, antibiotics, and surgical interventions, and best-practice pathways are an important part of quality programs. Advances in diagnostics and management, supported with outcome data, are impacting care pathways. This review provides an update on best practices related to the management of appendicitis and diverticulitis, with the goal of improving patient care, minimizing risk, and maximizing the patient experience.