Adenoid Cystic Carcinoma with Sebaceous Differentiation and MYB::NFIB Fusion Arising in the External Auditory Canal

Head Neck Pathol. 2024 Sep 23;18(1):85. doi: 10.1007/s12105-024-01689-4.

Abstract

Adenoid cystic carcinoma arising in the external auditory canal is rare, and even rarer are cases with sebaceous differentiation mimicking sebaceous carcinoma. This case with clinical, radiologic, gross, and histologic images exemplifies an unusual occurrence of adenoid cystic carcinoma in the external auditory canal with sebaceous differentiation, confirmed by MYB::NFIB fusion.

Keywords: MYB:NFIB fusion; Adenoid cystic carcinoma; External auditory canal; Sebaceous differentiation.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Adenoid Cystic* / genetics
  • Carcinoma, Adenoid Cystic* / pathology
  • Cell Differentiation
  • Ear Canal* / pathology
  • Ear Neoplasms* / genetics
  • Ear Neoplasms* / pathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oncogene Proteins, Fusion / genetics
  • Sebaceous Gland Neoplasms / genetics
  • Sebaceous Gland Neoplasms / pathology

Substances

  • Oncogene Proteins, Fusion
  • MYB-NFIB fusion protein, human