Identification of key genes and signaling pathways based on transcriptomic studies of aerobic and resistance training interventions in sarcopenia in SAMP8 mice

Lunyu Li; Xiaotian Guan; Ying Huang; Bo Qu; Binyu Yao; Haili Ding

doi:10.1016/j.smhs.2024.01.005

Identification of key genes and signaling pathways based on transcriptomic studies of aerobic and resistance training interventions in sarcopenia in SAMP8 mice

Sports Med Health Sci. 2024 Feb 15;6(4):358-369. doi: 10.1016/j.smhs.2024.01.005. eCollection 2024 Dec.

Authors

Lunyu Li¹, Xiaotian Guan¹, Ying Huang¹, Bo Qu¹, Binyu Yao¹, Haili Ding^{1

2}

Affiliations

¹ School of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.
² Institute of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.

Abstract

We examined the effects of resistance and aerobic exercise on the gene expression and biometabolic processes of aging skeletal muscle in senescence-accelerated mouse/prone 8 mice, a model of sarcopenia, and compared them with senescence-accelerated mouse/resistant 1 mice acting as controls. We found that exercise improved muscle strength, endurance, fiber size, also modulated genes and pathways related to synaptic transmission, potassium transport, JAK-STAT signaling, and PI3K-Akt signaling. Our results suggested that BDNF, JAK2, RhoC, Myh6, Stat5a, Tnnc1, and other genes may mediate the beneficial effects of exercise on sarcopenia through these pathways.

Keywords: Aerobic training; Resistance training; Sarcopenia; Transcriptome.