The role of heat shock proteins in HIV-1 pathogenesis: a systematic review investigating HSPs-HIV-1 correlations and interactions

Chyntia Tresna Nastiti; Noer Halimatus Syakdiyah; R M Firzha Hawari; Youdiil Ophinni; Ni Luh Ayu Megasari

doi:10.7717/peerj.18002

The role of heat shock proteins in HIV-1 pathogenesis: a systematic review investigating HSPs-HIV-1 correlations and interactions

PeerJ. 2024 Sep 19:12:e18002. doi: 10.7717/peerj.18002. eCollection 2024.

Authors

Chyntia Tresna Nastiti¹, Noer Halimatus Syakdiyah¹, R M Firzha Hawari¹, Youdiil Ophinni^{2

3}, Ni Luh Ayu Megasari^{4

5}

Affiliations

¹ Postgraduate School, Universitas Airlangga, Surabaya, East Java, Indonesia.
² Division of Clinical Virology, Graduate School of Medicine, Kobe University, Kobe, Japan.
³ Department of Environmental Coexistence, Center for Southeast Asian Studies, Kyoto University, Kyoto, Japan.
⁴ Immunology Program, Postgraduate School, Universitas Airlangga, Surabaya, East Java, Indonesia.
⁵ Institute of Tropical Disease, Universitas Airlangga, Surabaya, East Java, Indonesia.

Abstract

Background: The human immunodeficiency virus (HIV) pandemic is a global health emergency. Studies suggest a connection between heat shock proteins (HSPs) and HIV-1 infection pathogenesis. This systematic review aims to summarize HSPs' role in HIV-1 infection pathogenesis.

Materials and methods: A systematic literature search was undertaken across the National Library of Medicine (MEDLINE-PubMed), Science Direct, Web of Science, Scopus, SpringerLink, Sage, ProQuest, and Google Scholar databases, using related keywords to synthesize the HSPs' role in HIV-1 infection pathogenesis. This literature review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and the protocol was registered in the Open Science Framework (OSF) database under DOI 10.17605/OSF.IO/VK3DJ.

Results: A database search revealed 3,332 articles, with 14 in vitro studies analysing the interaction between HSPs and HIV-1 across different cell types. HSPs are involved in HIV-1 infection through direct interactions and indirect responses to cellular stress, including HSP40, HSP70, HSPBP1, and HSP90. The study explores HSP interactions at various stages of the viral life cycle, including entry, uncoating, replication, transmission, and latency reactivation.

Conclusion: HSPs are crucial for the HIV lifecycle and immune response, offering the potential for new therapeutic strategies. Further research is needed to understand the clinical significance and target potential.

Keywords: Heat shock proteins; Human immunodeficiency virus; Pathogenesis.

Publication types

Systematic Review

MeSH terms

HIV Infections* / immunology
HIV Infections* / metabolism
HIV Infections* / virology
HIV-1* / pathogenicity
Heat-Shock Proteins* / metabolism
Humans
Virus Replication

Substances

Heat-Shock Proteins

Grants and funding

Chyntia Tresna Nastiti received a scholarship from the Indonesia Endowment Fund for Education Agency (LPDP). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.