Case 1: A 27-year-old female with ALK-positive anaplastic large cell lymphoma/leukemia; Case 2: A 27-year-old male with acute myeloid leukemia; Case 3: A 56-year-old male with myelodysplastic syndrome. These three patients underwent haploid hematopoietic stem cell transplantation and experienced severe oral mucosal inflammation, nausea, vomiting, diarrhea, and other symptoms over a long period, which significantly restricted eating. Neurological and psychiatric symptoms appeared at 50, 38, and 50 days following transplantation, respectively. The diagnosis of Wernicke encephalopathy was made by head magnetic resonance imaging, whereas the condition improved significantly after intravenous infusion of vitamin B(1).
例1，女，27岁，ALK阳性间变性大细胞淋巴瘤/白血病（ALCL）；例2，男，27岁，急性髓系白血病；例3，男，56岁，骨髓增生异常综合征。3例患者单倍体造血干细胞移植后长期伴有重度口腔黏膜炎、恶心、呕吐、腹泻等症状，导致进食明显受限，分别于移植后50、38、50 d出现神经、精神症状，经头颅磁共振成像检查诊断为Wernicke脑病，经维生素B(1)静脉滴注治疗后病情明显好转。.