Quantitative aortic Na[18F]F positron emission tomography computed tomography as a tool to associate vascular calcification with major adverse cardiovascular events

T G F Lieverse; G D van Praagh; D J Mulder; H J Lambers Heerspink; J M Wolterink; R H J A Slart

doi:10.1007/s00259-024-06901-9

Quantitative aortic Na[¹⁸F]F positron emission tomography computed tomography as a tool to associate vascular calcification with major adverse cardiovascular events

Eur J Nucl Med Mol Imaging. 2024 Sep 19. doi: 10.1007/s00259-024-06901-9. Online ahead of print.

Authors

T G F Lieverse^#¹, G D van Praagh^#², D J Mulder³, H J Lambers Heerspink⁴, J M Wolterink⁵, R H J A Slart^{2

6}

Affiliations

¹ Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. t.g.f.lieverse@umcg.nl.
² Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
³ Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
⁴ Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
⁵ Department of Applied Mathematics and Technical Medical Center, University of Twente, Enschede, The Netherlands.
⁶ Department of Biomedical Photonic Imaging, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands.

^# Contributed equally.

PMID: 39297960
DOI: 10.1007/s00259-024-06901-9

Abstract

Purpose: Sodium[¹⁸F]fluoride (Na[¹⁸F]F) used in positron emission tomography (PET) binds to active calcification and correlates consistently with higher cardiovascular risk. This study aims to investigate the feasibility of aortic Na[¹⁸F]F-PET in hybrid combination with low-dose computed tomography (CT) as a risk model for major adverse cardiovascular events (MACE).

Methods: Patient data and Na[¹⁸F]F-PET/CT scans from January 2019 to February 2022 were retrospectively collected at the University Medical Center Groningen (UMCG), the Netherlands. MACE-outcome was a composite of time to first documented myocardial infarction, cerebral vascular accident (CVA), acute heart failure hospitalization, and aortic aneurysms. MACE dates were recorded from the day of the scan until follow-up in December 2023. The aorta was manually segmented in all low-dose CT scans. To minimize spill-over effects from the vertebrae, the vertebrae were automatically segmented using an open-source model, dilated with 10 mm, and subtracted from the aortic mask. The total aortic Na[¹⁸F]F corrected maximum standardized uptake value (cSUV_max) and total aortic Agatston score were automatically calculated using SEQUOIA. Kaplan-Meier and Cox regression survival analysis were performed, stratifying patients into high, medium, and low cSUV_max and Agatston categories. Cox regression models were adjusted for age.

Results: Out of 280 identified scans, 216 scans of unique patients were included. During a median follow-up of 3.9 years, 12 MACE occurred. Kaplan-Meier survival analysis demonstrated a significant difference in MACE-free survival among the high cSUV_max group compared to the medium and low groups (p = 0.03 and p < 0.01, respectively). Similarly, patients with high Agatston scores had a significantly lower MACE-free survival probability compared to those with medium and low scores (both p < 0.01).

Conclusion: This study highlights the potential clinical utility of Na[¹⁸F]F-PET/CT as an imaging tool to predict the risk of MACE. Clinical validation of this novel proof-of-concept method is needed to confirm these results and expand the clinical context.

Keywords: Agatston score; CVD; MACE; Na[18F]F; PET/CT.