Stopping Trials Early for Benefit: Insights From Recent Pivotal Trials in Chronic Kidney Disease

J Am Coll Cardiol. 2024 Sep 24;84(13):1268-1271. doi: 10.1016/j.jacc.2024.07.026.

Authors

Sanjay Kaul¹, Javed Butler²

Affiliations

¹ Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address: kaul@cshs.org.
² Baylor Scott & White Research Institute, Dallas, Texas, USA; University of Mississippi, Jackson, Mississippi, USA. Electronic address: javed.butler@bswhealth.org.

PMID: 39293886
DOI: 10.1016/j.jacc.2024.07.026

No abstract available

Keywords: clinical trials; diabetic nephropathy; early stopping; interim analysis; stopping boundaries.

Publication types

Editorial

MeSH terms

Cardiovascular Diseases / therapy
Clinical Trials as Topic
Early Termination of Clinical Trials
Humans
Randomized Controlled Trials as Topic / methods
Renal Insufficiency, Chronic* / therapy