RH5: rationally-designed malaria vaccine antigen improving efficacy

Abstract

Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) is a unique asexual blood-stage malaria vaccine candidate because of its high conservation and essential biological function of binding to basigin on the erythrocyte surface. Recent studies by Barrett et al., Wang et al., and King et al., have brought RH5-based vaccine development a step forward based on a rational antigen design strategy.

Keywords: Plasmodium falciparum; RH5; VLP; blood-stage malaria vaccine; epitope mapping; human monoclonal antibodies.