[Role and mechanism of autonomic nervous system regulation in primary glaucoma]

Zhonghua Yan Ke Za Zhi. 2024 Sep 11;60(9):780-786. doi: 10.3760/cma.j.cn112142-20231103-00203.
[Article in Chinese]

Abstract

The regulation of blood flow in the human eye, aqueous humor production, and the outflow channels of aqueous humor are all controlled by the autonomic nervous system (ANS), encompassing both sympathetic and parasympathetic nerves. Patients with primary glaucoma often exhibit autonomic nervous system dysfunctions, which may exacerbate visual impairment. The homeostasis of the autonomic nervous system is influenced by circadian rhythms, physical exercise, emotional states, medications, and other factors. Previous studies have indicated that activities such as aerobic exercise, yoga breathing, and meditation can promote the restoration of autonomic nervous system balance, thereby reducing intraocular pressure. However, further evidence is required to substantiate the efficacy of ANS activity regulation as an effective adjunct therapy for primary glaucoma. This review examines the role and mechanisms of autonomic nervous system regulation in the context of primary glaucoma.

人眼血流、房水生成速率和房水流出通道均受自主神经系统(交感神经和副交感神经)的调控,原发性青光眼患者往往伴有自主神经系统功能异常,而且自主神经系统功能异常有可能促进青光眼患者视功能的进一步损伤。自主神经系统的稳态受到昼夜节律、运动、精神心理以及药物等因素的影响,既往研究发现,有氧运动、瑜伽呼吸法、冥想等活动可促进自主神经系统稳态的恢复,且有降低眼压的作用。但是,调节自主神经系统的活动可成为原发性青光眼有效的辅助治疗方法仍需要更多证据证明。本文就自主神经系统调控在原发性青光眼中的作用及机制作一综述。.

Publication types

  • Review
  • English Abstract

MeSH terms

  • Aqueous Humor / physiology
  • Autonomic Nervous System* / physiopathology
  • Glaucoma* / physiopathology
  • Glaucoma* / therapy
  • Humans
  • Intraocular Pressure / physiology