Factors affecting the development of cystoid macular edema following pars plana vitrectomy with silicone oil placement: a retrospective cohort study

Reem H ElSheikh; Sairi Zhang; Muhammad Z Chauhan; Riley N Sanders; Sami H Uwaydat

doi:10.1186/s40942-024-00582-0

Factors affecting the development of cystoid macular edema following pars plana vitrectomy with silicone oil placement: a retrospective cohort study

Int J Retina Vitreous. 2024 Sep 12;10(1):64. doi: 10.1186/s40942-024-00582-0.

Authors

Reem H ElSheikh¹, Sairi Zhang², Muhammad Z Chauhan¹, Riley N Sanders¹, Sami H Uwaydat³

Affiliations

¹ Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Slot # 523, Little Rock, AR, 72205, USA.
² College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
³ Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Slot # 523, Little Rock, AR, 72205, USA. SHUwaydat@uams.edu.

Abstract

Background: Cystoid macular edema (CME) can develop following silicone oil placement in complex vitreoretinal surgeries, contributing to poor visual outcomes. In this study, we investigated the clinical and surgical characteristics associated with the development of CME following the use of silicone oil (SO) in pars plana vitrectomy (PPV) surgeries.

Methods: We conducted a retrospective chart review of patients who underwent implantation of SO during PPV from 2010 to 2020 by a single surgeon. Patient demographics, type of oil, duration of oil tamponade, retinectomy size, diabetic status, lens status, prior panretinal photocoagulation, visual acuity, and incidence of CME were reviewed.

Results: This study included 43 eyes from 40 patients who underwent SO tamponade for retinal detachment (RD) surgery. The mean duration of SO tamponade was 15.7 ± 12.7 months (range: 1-58 months). The most common indication for surgery was diabetic tractional RD (32.7%), followed by traumatic RD (16.3%) and rhegmatogenous RD with proliferative vitreoretinopathy (11.6%). Of the 43 eyes, 18 (41.9%) developed CME for the first time after PPV with SO placement, with 8 (44%) resolving within a year of oil removal. The mean duration for the development of CME was 9 months. A logistic regression model showed that a scleral buckle procedure and poor initial vision were statistically significant factors for predicting the development of CME (ORs: 11.65 and 16.06, respectively). Overall, 91% of the patients had stable or improved vision after surgery.

Conclusions: The use of a scleral buckle procedure and poor initial vision are significant factors for predicting CME following silicone oil tamponade in PPV surgeries, with 41.9% of patients developing CME with an average duration of 9 months. Recognizing such factors can lead to early monitoring and prompt management of CME.

Meeting presentation: Partial analyses were presented at the ASRS 2020 conference.

Clinical trial number: Not applicable.

Keywords: Cystoid macular edema; Pars plana vitrectomy; Retinal detachment; Scleral buckle; Silicone oil; Surgical outcomes.