Intraosseous myofibroma mimicking an odontogenic lesion: case report, literature review, and differential diagnosis

World J Surg Oncol. 2024 Sep 12;22(1):246. doi: 10.1186/s12957-024-03520-4.

Abstract

Background: Intraosseous myofibroma of the jaw is a rare neoplasm of mesenchymal origin with limited comprehensive understanding. It typically affects patients in the first two decades of life with a male predilection.

Case presentation: This study presents a rare case of myofibroma mimicking an odontogenic lesion in a 2-year-old boy. The patient presented with an incidental finding of a painless swelling of the right mandibular ramus of unknown etiology. Imaging analysis revealed a solid, expansile lesion adjacent to the germinal zone of the right mandibular first molar. Histopathologic analysis and immunohistochemistry after incisional biopsy suggested a possible central odontogenic fibroma, and the patient underwent total enucleation, leading to the final diagnosis of intraosseous myofibroma. Follow-up examinations showed no evidence of recurrence.

Conclusions: This report contributes to the understanding of myofibroma in pediatric patients and underscores the critical role of meticulous histopathologic examination for effective surgical planning and optimal patient outcomes.

Keywords: Case report; Myofibroma; Oral Pathology; Oral surgery; Pediatrics.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Child, Preschool
  • Diagnosis, Differential
  • Humans
  • Male
  • Mandibular Neoplasms* / diagnosis
  • Mandibular Neoplasms* / diagnostic imaging
  • Mandibular Neoplasms* / pathology
  • Mandibular Neoplasms* / surgery
  • Myofibroma* / diagnosis
  • Myofibroma* / diagnostic imaging
  • Myofibroma* / pathology
  • Myofibroma* / surgery
  • Odontogenic Tumors* / diagnosis
  • Odontogenic Tumors* / diagnostic imaging
  • Odontogenic Tumors* / pathology
  • Odontogenic Tumors* / surgery
  • Prognosis