Multiple Gastrointestinal Immune-Related Adverse Events From Immune Checkpoint Inhibitor Therapy

Abstract

Introduction: We aimed to describe immune-related adverse events (irAEs) affecting multiple organs of the gastrointestinal system in patients who received immune checkpoint inhibitors.

Methods: Within a 2,843 patient retrospective cohort consisting of patients with cancer treated with immune checkpoint inhibitors, we used the Electronic Medical Record Search Engine, an information retrieval system, to search free text in the medical record to identify patients with multiple gastrointestinal irAEs.

Results: Thirteen patients developed multiple gastrointestinal irAEs (0.46%). The most common patterns of multisystem gastrointestinal irAE were colitis + pancreatitis and colitis + enteritis.

Discussion: Multisystem gastrointestinal irAEs are rare but warrant further characterization and attention.