The Sirt1/Nrf2 pathway is a key factor for drug therapy in chemotherapy-induced cardiotoxicity: a Mini-Review

Suleiman Ibrahim Shelash Mohammad; Asokan Vasudevan; Felix Oghenemaro Enwa; Jaya Bansal; Mamata Chahar; Mamdouh Eldesoqui; Muhammad Ikram Ullah; Zhanna R Gardanova; Hanen Mahmod Hulail; Ahmed Hussein Zwamel

doi:10.1007/s12032-024-02494-3

The Sirt1/Nrf2 pathway is a key factor for drug therapy in chemotherapy-induced cardiotoxicity: a Mini-Review

Med Oncol. 2024 Sep 11;41(10):244. doi: 10.1007/s12032-024-02494-3.

Authors

Affiliations

¹ Research Follower, INTI International University, 71800, Nilai, Negeri Sembilan, Malaysia. dr_sliman73@aabu.edu.jo.
² Department of Business Administration, Business School, Al Al-Bayt University, Al-Mafraq, Jordan. dr_sliman73@aabu.edu.jo.
³ Faculty of Business and Communications, INTI International University, 71800, Nilai, Negeri Sembilan, Malaysia.
⁴ Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Delta State University, Abraka, Delta State, Nigeria.
⁵ Chandigarh Pharmacy College, Chandigarh Group of Colleges, Jhanjeri, Mohali, Punjab, 140307, India.
⁶ Department of Chemistry, NIMS Institute of Engineering & Technology, NIMS University Rajasthan, Jaipur, India.
⁷ Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Diriyah, 13713, Riyadh, Saudi Arabia. mamrah@um.edu.sa.
⁸ Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, 72388, Sakaka, Aljouf, Saudi Arabia.
⁹ Department of Psychotherapy, Pirogov Russian National Research Medical University, 117997, Moscow, Russia.
¹⁰ Department of Fundamental Disciplines, Independent Non-Profit Organization of Higher Education, "Medical University MGIMO-MED", Moscow, Russia.
¹¹ Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
¹² Medical Laboratory Technique College, The Islamic University, Najaf, Iraq.
¹³ Medical Laboratory Technique College, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.
¹⁴ Medical Laboratory Technique College, The Islamic University of Babylon, Babylon, Iraq.

PMID: 39259412
DOI: 10.1007/s12032-024-02494-3

Abstract

The likelihood of survival for cancer patients has greatly improved due to chemotherapy medicines. However, these antitumor agents might also have unfavorable effects on the cardiovascular system, which could result in sudden or gradual cardiac failure. The production of free radicals that result in oxidative stress appears to be the key mechanism by which chemotherapy-induced cardiotoxicity (CIC) happens. Reports suggest that the Sirtuin-1 (Sirt1)/Nuclear factor E2-associated factor 2 (Nrf2) signaling pathway has been considered an alternative path for counteracting cardiotoxicity by suppressing oxidative stress, inflammation, and apoptosis. This review concludes recent knowledge about CIC with a special focus on the anti-oxidative regulation properties of the Sirt1/Nrf2 pathway.

Keywords: Cardiotoxicity; Chemotherapy; Oxidative stress; Sirt1/Nrf2 pathway.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents* / adverse effects
Cardiotoxicity* / etiology
Humans
NF-E2-Related Factor 2* / metabolism
Neoplasms / drug therapy
Neoplasms / metabolism
Oxidative Stress / drug effects
Signal Transduction* / drug effects
Sirtuin 1* / metabolism

Substances

Sirtuin 1
NF-E2-Related Factor 2
Antineoplastic Agents
SIRT1 protein, human
NFE2L2 protein, human