Core-size and geometry versus toxicity in small amino terminated PAMAM dendrimers

Claus Bøge Hansen; Anna Janaszewska; Monika Dąbrzalska; Monika Marcinkowska; Barbara Klajnert-Maculewicz; Jørn Bolstad Christensen

doi:10.1039/d4ra02020k

Core-size and geometry versus toxicity in small amino terminated PAMAM dendrimers

RSC Adv. 2024 Sep 10;14(39):28684-28692. doi: 10.1039/d4ra02020k. eCollection 2024 Sep 4.

Authors

Claus Bøge Hansen¹, Anna Janaszewska², Monika Dąbrzalska², Monika Marcinkowska², Barbara Klajnert-Maculewicz², Jørn Bolstad Christensen¹

Affiliations

¹ Department of Chemistry, Faculty of Science, University of Copenhagen Thorvaldsensvej 40 DK-1871 Frederiksberg Denmark jbc@chem.ku.dk.
² Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz 141/143 Pomorska Street 90-236 Lodz Poland.

Abstract

A series of 6 small PAMAM dendrimers (G0-dendrimers) differing in the size, polarity and flexibility has been synthesized. The toxicity has been investigated in three different human cancer cell lines (HeLa, MCF-7, THP-1) and the endothelial skin cell line HMEC-1 in order to evaluate their potential as vehicles for drug delivery.