Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals

Nachshon Korem; Ansel T Hillmer; Deepak Cyril D'Souza; Anahita Bassir Nia; Ifat Levy; Robert H Pietrzak; Ilan Harpaz-Rotem

doi:10.1001/jamanetworkopen.2024.32387

Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals

JAMA Netw Open. 2024 Sep 3;7(9):e2432387. doi: 10.1001/jamanetworkopen.2024.32387.

Authors

Nachshon Korem^{1

2

3}, Ansel T Hillmer^{1

4

5

6}, Deepak Cyril D'Souza^{1

3}, Anahita Bassir Nia¹, Ifat Levy^{2

6

7

8}, Robert H Pietrzak^{1

3}, Ilan Harpaz-Rotem^{1

3

6

7}

Affiliations

¹ Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
² Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut.
³ US Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, Connecticut.
⁴ Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
⁵ Department of Biomedical Engineering, Yale School of Engineering and Applied Sciences, Yale University, New Haven, Connecticut.
⁶ Wu Tsai Institute, Yale University New Haven, New Haven, Connecticut.
⁷ Department of Psychology, Yale University, New Haven, Connecticut.
⁸ Department of Neuroscience, Yale University, New Haven, Connecticut.

No abstract available

Plain language summary

This case-control study assesses associations of amygdala cannabinoid 1 receptor availability with amygdala response to shock-induced pain and severity of emotional numbing symptoms of veterans with posttraumatic stress disorder.

MeSH terms

Adult
Amygdala* / physiopathology
Emotions / physiology
Female
Humans
Magnetic Resonance Imaging
Male
Pain / psychology
Receptor, Cannabinoid, CB1*
Stress Disorders, Post-Traumatic / psychology
Young Adult

Substances

Receptor, Cannabinoid, CB1

Grants and funding

I01 CX001538/CX/CSRD VA/United States