CYP3A4 and CYP3A5 are the most abundant and important enzymes of the CYP3A subfamily, distributed in the liver, intestinal mucosa and kidney, and involved in tacrolimus metabolism. Here, we report a case of tacrolimus dosage refractoriness due to a genetic polymorphism of CYP3A5.
Keywords: CYP3A5; intestinal absorption; kidney transplantation; tacrolimus; therapeutic drug monitoring.
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