RNA dynamics from experimental and computational approaches

Giovanni Bussi; Massimiliano Bonomi; Paraskevi Gkeka; Michael Sattler; Hashim M Al-Hashimi; Pascal Auffinger; Maria Duca; Yann Foricher; Danny Incarnato; Alisha N Jones; Serdal Kirmizialtin; Miroslav Krepl; Modesto Orozco; Giulia Palermo; Samuela Pasquali; Loïc Salmon; Harald Schwalbe; Eric Westhof; Martin Zacharias

doi:10.1016/j.str.2024.07.019

RNA dynamics from experimental and computational approaches

Structure. 2024 Sep 5;32(9):1281-1287. doi: 10.1016/j.str.2024.07.019.

Authors

Giovanni Bussi¹, Massimiliano Bonomi², Paraskevi Gkeka³, Michael Sattler⁴, Hashim M Al-Hashimi⁵, Pascal Auffinger⁶, Maria Duca⁷, Yann Foricher⁸, Danny Incarnato⁹, Alisha N Jones¹⁰, Serdal Kirmizialtin¹¹, Miroslav Krepl¹², Modesto Orozco¹³, Giulia Palermo¹⁴, Samuela Pasquali¹⁵, Loïc Salmon¹⁶, Harald Schwalbe¹⁷, Eric Westhof¹⁸, Martin Zacharias¹⁹

Affiliations

¹ Scuola Internazionale Superiore di Studi Avanzati (SISSA), Via Bonomea 265, 34136 Trieste, Italy. Electronic address: bussi@sissa.it.
² Institut Pasteur, Université Paris Cité, CNRS UMR 3528, Computational Structural Biology Unit, Paris, France. Electronic address: mbonomi@pasteur.fr.
³ Integrated Drug Discovery, Molecular Design Sciences, Sanofi, Vitry-sur-Seine, France. Electronic address: paraskevi.gkeka@sanofi.com.
⁴ Technical University of Munich, Munich, Germany; Helmholtz Munich, Munich, Germany. Electronic address: michael.sattler@helmholtz-munich.de.
⁵ Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
⁶ Université de Strasbourg, Architecture et Réactivité de l'ARN, Institut de Biologie Moléculaire et Cellulaire du CNRS, 2 Allée Konrad Roentgen, 67084 Strasbourg, France.
⁷ Université Côte d'Azur, CNRS, Institute of Chemistry of Nice, Nice, France.
⁸ Integrated Drug Discovery, Small Molecules Medicinal Chemistry, Sanofi, Vitry-sur-Seine, France.
⁹ Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, the Netherlands.
¹⁰ Department of Chemistry, New York University, New York, NY, USA.
¹¹ Department of Chemistry, New York University, New York, NY, USA; Chemistry Program, Science Division, New York University, Abu Dhabi, United Arab Emirates.
¹² Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, Brno 612 00, Czech Republic.
¹³ Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, and Department of Biochemistry and Biomedicine, University of Barcelona, Barcelona, Spain.
¹⁴ Department of Bioengineering and Department of Chemistry, The University of California, Riverside, Riverside, CA, USA.
¹⁵ Laboratoire Biologie Fonctionnelle et Adaptative, CNRS UMR 8251 INSERM ERL 1133, Université Paris Cité, 35 rue Hélène Brion, 75013 Paris, France.
¹⁶ Centre de RMN à Très Hauts Champs, UMR 5082 (CNRS, École Normale Supérieure de Lyon, Université Claude Bernard Lyon 1), University of Lyon, 69100 Villeurbanne, France.
¹⁷ Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Goethe-University Frankfurt, 60438 Frankfurt/Main, Germany.
¹⁸ Architecture et Réactivité de l'ARN, Université de Strasbourg, Institut de biologie moléculaire et cellulaire du CNRS, 67084 Strasbourg, France.
¹⁹ Physics Department and Center of Protein Assemblies, Technical University of Munich, Munich, Germany.

PMID: 39241758
DOI: 10.1016/j.str.2024.07.019

Abstract

Conformational dynamics is crucial for the biological function of RNA molecules and for their potential as therapeutic targets. This meeting report outlines key "take-home" messages that emerged from the presentations and discussions during the CECAM workshop "RNA dynamics from experimental and computational approaches" in Paris, June 26-28, 2023.

Publication types

Congress
Clinical Conference

MeSH terms

Computational Biology / methods
Humans
Molecular Dynamics Simulation*
Nucleic Acid Conformation*
RNA* / chemistry
RNA* / metabolism

Substances

RNA