Humans are unreliable models of mouse disease

Cell. 2024 Sep 5;187(18):4814-4818. doi: 10.1016/j.cell.2024.08.006.

Abstract

In defying conventional views that dismissed itch as trivial, I persisted in studying basophils and ILC2s in human skin and atopic dermatitis. My research on JAK inhibitors for itch ultimately led to FDA-approved drugs. This is my story of disregarding categories and definitions-a story about an unconventional path in science that emphasizes innovation over conformity.

Publication types

  • Historical Article

MeSH terms

  • Animals
  • Basophils / metabolism
  • Dermatitis, Atopic* / drug therapy
  • Dermatitis, Atopic* / immunology
  • Dermatitis, Atopic* / pathology
  • Disease Models, Animal*
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Janus Kinase Inhibitors / pharmacology
  • Janus Kinase Inhibitors / therapeutic use
  • Mice
  • Pruritus*
  • Skin / metabolism
  • Skin / pathology

Substances

  • Janus Kinase Inhibitors