Updates in Molecular Profiling of Pancreatic Ductal Adenocarcinoma

Abstract

Outcomes from pancreatic ductal adenocarcinoma (PDAC) remain poor and better methods of prognostication and therapeutic approaches are needed. Recent advances in cancer genomics have led to the development of molecular subtypes of PDAC associated with clinical outcomes. Current evidence also suggests that the subtypes have differential response to first-line chemotherapy regimens. PDAC is also characterized by different stroma and immune environments. Further work is needed to confirm the utility of these subtypes to predicting response to different systemic therapies.

Keywords: Cancer genomics; Molecular subtyping; Next-generation sequencing; Pancreatic cancer; Precision oncology.