Deciphering the molecular landscape of the FAM72 gene family: Implications for stem cell biology and cancer

Janani Ramesh; Raja Mohan Gopalakrishnan; Tuan Hoang Anh Nguyen; Soak-Kuan Lai; Hoi-Yeung Li; Pok-Son Kim; Arne Kutzner; Noriko Inoue; Klaus Heese

doi:10.1016/j.neuint.2024.105853

Deciphering the molecular landscape of the FAM72 gene family: Implications for stem cell biology and cancer

Neurochem Int. 2024 Sep 3:180:105853. doi: 10.1016/j.neuint.2024.105853. Online ahead of print.

Authors

Janani Ramesh¹, Raja Mohan Gopalakrishnan², Tuan Hoang Anh Nguyen³, Soak-Kuan Lai⁴, Hoi-Yeung Li⁵, Pok-Son Kim⁶, Arne Kutzner⁷, Noriko Inoue⁸, Klaus Heese⁹

Affiliations

¹ Department of Medical Biochemistry, Dr ALM Postgraduate Institute of Biomedical Sciences, University of Madras, Chennai, Tamil Nadu, 600-113, India. Electronic address: rjjananiramesh95@gmail.com.
² Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, Tamil Nadu, 600-025, India. Electronic address: rgrajamohan@yahoo.com.
³ Graduate School of Biomedical Science and Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 133-791, Republic of Korea. Electronic address: nhanhtuan@hanyang.ac.kr.
⁴ School of Biological Sciences, College of Science, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637-551, Singapore. Electronic address: SKLai@ntu.edu.sg.
⁵ School of Biological Sciences, College of Science, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637-551, Singapore. Electronic address: hyli@ntu.edu.sg.
⁶ Department of Information Security, Cryptology, and Mathematics, Kookmin University, Seoul, 136-702, Republic of Korea. Electronic address: pskim@kookmin.ac.kr.
⁷ Department of Information Systems, College of Computer Science, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 133-791, Republic of Korea. Electronic address: kutzner@hanyang.ac.kr.
⁸ Osaka University Institute for Sports and Global Health, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address: noriko.phs@osaka-u.ac.jp.
⁹ Graduate School of Biomedical Science and Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 133-791, Republic of Korea. Electronic address: klaus@hanyang.ac.kr.

PMID: 39236808
DOI: 10.1016/j.neuint.2024.105853

Abstract

Family with sequence similarity 72 (FAM72) is a protein-coding gene family located on chromosome 1 in humans, uniquely featuring four paralogs: FAM72A, FAM72B, FAM72C, and FAM72D. While FAM72's presence as a gene pair with the SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) is intriguing, its functional roles, particularly in neural stem cells, remain incompletely understood. This review explores the distinct characteristics of FAM72, shedding light on its expression patterns, potential roles in cell cycle regulation, stem cell renewal and implications in neurogenesis and tumorigenesis.

Keywords: Cell cycle; DNA repair; FOXM1; Glioblastoma; Proliferation; Stem cell; UNG.

Publication types

Review