Localized tacrolimus therapy: innovations in peripheral nerve regeneration through advanced drug delivery systems

Ther Deliv. 2024;15(10):743-748. doi: 10.1080/20415990.2024.2392481. Epub 2024 Sep 4.

Authors

Elena Millesi^{1

2}, Flavia Millesi², Julian S Rechberger³, David J Daniels³, Christine Radtke², Samir Mardini¹

Affiliations

¹ Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, MN 55905, USA.
² Division of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, 1090, Austria.
³ Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905,USA.

PMID: 39229814
PMCID: PMC11457664 (available on 2025-09-04)
DOI: 10.1080/20415990.2024.2392481

No abstract available

Keywords: FK506; axonal acceleration; calcineurin inhibitor; local drug delivery; nerve injury; nerve regeneration; nerve repair.

Publication types

Editorial

MeSH terms

Animals
Drug Delivery Systems* / methods
Humans
Immunosuppressive Agents / administration & dosage
Immunosuppressive Agents / pharmacokinetics
Nerve Regeneration* / drug effects
Peripheral Nerves / drug effects
Tacrolimus* / administration & dosage
Tacrolimus* / pharmacokinetics

Substances

Tacrolimus
Immunosuppressive Agents