Association between celiac disease and fibromyalgia and their severity: a cross-sectional study

PeerJ. 2024 Aug 30:12:e17949. doi: 10.7717/peerj.17949. eCollection 2024.

Abstract

Background: Fibromyalgia (FMS) is a common musculoskeletal disorder with many causes. People with fibromyalgia often have the same symptoms as people with celiac disease (CD). Demonstration of the coordination and frequency of FMS and CD is important for effective treatment.

Methods: This is a single center cross-sectional clinical study. The study included 60 patients who were diagnosed with CD by the Gastroenterology Clinic based on American College of Gastroenterology (ACG) criteria. Patients were also asked to complete the Widespread Pain Index (WPI), Symptom Severity Scale (SSS), and Fibromyalgia Impact Questionnaire (FIQ) to diagnose fibromyalgia and assess its severity. The results were used to analyze the frequency of concomitance and relationship between the two diseases.

Results: The relationship between the clinical types of CD and the presence of fibromyalgia was insignificant. Analysis of the relationship between the pathologic typing of biopsy and fibromyalgia frequency was insignificant. Those with antibodies more frequently met criteria for fibromyalgia (P = 0.04, P = 0.04, respectively).

Conclusions: Presence of clinical extraintestinal manifestations in patients with CD should lead clinicians to consider FMS as a possible diagnosis. This points to the importance for clinicians in all subspecialties to be aware of the various symptoms and diseases associated with FMS.

Keywords: Antibodies; Celiac disease; Enteropathy; Fibromyalgia; Pain.

MeSH terms

  • Adult
  • Celiac Disease* / complications
  • Celiac Disease* / diagnosis
  • Celiac Disease* / pathology
  • Cross-Sectional Studies
  • Female
  • Fibromyalgia* / diagnosis
  • Fibromyalgia* / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Pain Measurement / methods
  • Severity of Illness Index*
  • Surveys and Questionnaires

Grants and funding

The authors received no funding for this work.