Sex-related differences in ST-segment elevation myocardial infarction: A Portuguese multicenter national registry analysis

Carolina Miguel Gonçalves; Mariana Carvalho; Adriana Vazão; Margarida Cabral; André Martins; Fátima Saraiva; João Morais; ProACS Investigators

doi:10.1016/j.repc.2024.06.005

Sex-related differences in ST-segment elevation myocardial infarction: A Portuguese multicenter national registry analysis

Rev Port Cardiol. 2024 Aug 29:S0870-2551(24)00272-5. doi: 10.1016/j.repc.2024.06.005. Online ahead of print.

[Article in English, Portuguese]

Authors

Carolina Miguel Gonçalves¹, Mariana Carvalho², Adriana Vazão², Margarida Cabral², André Martins², Fátima Saraiva², João Morais³; ProACS Investigators

Affiliations

¹ Unidade Local de Saúde da Região de Leiria, E.P.E., Leiria, Portugal. Electronic address: carolinagoncalves9@gmail.com.
² Unidade Local de Saúde da Região de Leiria, E.P.E., Leiria, Portugal.
³ Unidade Local de Saúde da Região de Leiria, E.P.E., Leiria, Portugal; ciTechCare - Center for Innovative Care and Health Technology, Polytechnique of Leiria, Leiria, Portugal.

PMID: 39216527
DOI: 10.1016/j.repc.2024.06.005

Abstract

Introduction and objectives: Sex differences among patients with acute myocardial infarctions remain a matter of debate. Inequalities in presentation, diagnosis, treatment, and prognosis are frequently observed, contributing to a worse prognosis in women. The aim of this study was to investigate sex-related differences in Portuguese ST-segment elevation myocardial infarction (STEMI) patients.

Methods: The authors conducted a retrospective analysis of STEMI patients included in the Portuguese Registry on Acute Coronary Syndromes, between October 2010 and 2022. The two co-primary endpoints were in-hospital and one-year mortality.

Results: A total of 14470 STEMI patients were studied. Women were underrepresented with 3721 individuals (25.7%). They were significantly older (70 vs. 62 years, p<0.001), with higher prevalence of cardiovascular risk factors, and underwent less frequently coronary angiography (84.4% vs. 88.5%, p<0.001) and guideline-directed medical therapy (e.g., aspirin 92.5% vs. 95.4%, beta blockers 79.2% vs. 83%, p<0.001). Furthermore, they experienced more complications, such as congestive heart failure (23.4% vs. 14.6%), ischemic stroke (47% vs. 40%), and in-hospital mortality (8.5% vs. 4.1%) (p<0.001 for all comparisons). Similarly, they presented higher one-year mortality (11.5% vs. 6.3%, p<0.001). However, after a multivariate analysis testing significant clinical variables, female sex remained an independent predictor for in-hospital (odds ratio=1.633; 95% CI [1.065-2.504]; p=0.025), but not for one-year mortality.

Conclusions: This analysis reveals sex-related disparities in Portuguese STEMI patients. Despite limitations inherent to registry-based analysis, women were significantly older, with increased cardiovascular risk, less treated, and with higher in-hospital mortality. These disparities should be a concern for clinicians to further improve outcomes and move toward equitable medical care.

Keywords: Diagnosis; Diagnóstico; Diferenças entre sexos; Enfarte agudo do miocárdio; Myocardial infarction; Prognosis; Prognóstico; STEMI; Sex differences; Tratamento; Treatment.