Clinical application of phage immunoprecipitation sequencing to diagnose enterovirus D68 as the underlying etiology in a case of Gullain-Barré syndrome

Fang Fang Li; Alison Faber; Jessica M Caleta; David M Goldfarb; Inna Sekirov; Natalie A Prystajecky; Jocelyn A Srigley; Ram Mishaal; Agatha N Jassem

doi:10.1093/infdis/jiae411

Clinical application of phage immunoprecipitation sequencing to diagnose enterovirus D68 as the underlying etiology in a case of Gullain-Barré syndrome

J Infect Dis. 2024 Aug 31:jiae411. doi: 10.1093/infdis/jiae411. Online ahead of print.

Authors

Fang Fang Li¹, Alison Faber^{2

3}, Jessica M Caleta⁴, David M Goldfarb^{1

5

6}, Inna Sekirov^{1

4}, Natalie A Prystajecky^{1

4}, Jocelyn A Srigley^{1

5

6}, Ram Mishaal^{2

3

6}, Agatha N Jassem^{1

4}

Affiliations

¹ Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 1Z7, Canada.
² Department of Pediatrics, University of British Columbia, Vancouver, BC, V6H 3V4, Canada.
³ Sunny Hill Health Centre, British Columbia Children's Hospital, Vancouver, BC, V6H 3N1, Canada.
⁴ Public Health Laboratory, British Columbia Centre for Disease Control, Vancouver, BC, V5Z 4R4, Canada.
⁵ British Columbia Children's and Women's Hospitals, Vancouver, BC, V6H 3N1, Canada.
⁶ British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada.

PMID: 39215587
DOI: 10.1093/infdis/jiae411

Abstract

Gullain-Barré syndrome (GBS) is an acute peripheral neuropathy often preceded by respiratory or gastrointestinal infections, though molecular testing of cerebrospinal fluid (CSF) is often inconclusive. In a recent case of severe pediatric GBS in British Columbia, Canada, we detected CSF antibodies against enterovirus D (EV-D) to link GBS with prior EV-D68 respiratory infection.

Keywords: Enterovirus D68; Guillain-Barré syndrome; Phage immunoprecipitation sequencing.

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