Evaluation of Transplacental Maternal SARS-CoV-2 Antibody Transfer in Small for Gestational Age Infants

Alisa Kachikis; Mindy Pike; Linda O Eckert; Emma A Roberts; Alexis Baranoff; Sharon Kung; Erin A Goecker; Michael G Gravett; Alexander L Greninger; Janet A Englund

doi:10.1093/jpids/piae085

Evaluation of Transplacental Maternal SARS-CoV-2 Antibody Transfer in Small for Gestational Age Infants

J Pediatric Infect Dis Soc. 2024 Nov 27;13(11):585-588. doi: 10.1093/jpids/piae085.

Authors

Alisa Kachikis¹, Mindy Pike¹, Linda O Eckert^{1

2}, Emma A Roberts³, Alexis Baranoff⁴, Sharon Kung¹, Erin A Goecker⁵, Michael G Gravett^{1

2}, Alexander L Greninger⁵, Janet A Englund⁶

Affiliations

¹ Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.
² Department of Obstetrics and Gynecology, Department of Global Health, University of Washington, Seattle, Washington, USA.
³ Department of Obstetrics and Gynecology, University of California San Diego, San Diego, California, USA.
⁴ University of Washington School of Medicine, Seattle, Washington, USA.
⁵ Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
⁶ Department of Pediatrics, University of Washington, Seattle Children's Research Institute, Seattle, Washington, USA.

Abstract

Little is known about the potential benefits of maternal immunization in the setting of high-risk pregnancies resulting in small-for-gestational-age (SGA) infants. This study compares transplacental transfer of maternal SARS-CoV-2 anti-Spike antibody in pregnancies with SGA compared to appropriate-for-gestational-age infants.

Keywords: SARS-CoV-2; maternal immunization; small-for-gestational-age infant; transplacental antibody transfer; vaccination in pregnancy.

MeSH terms

Adult
Antibodies, Viral* / blood
COVID-19* / immunology
Female
Humans
Immunity, Maternally-Acquired*
Infant, Newborn
Infant, Small for Gestational Age* / immunology
Maternal-Fetal Exchange / immunology
Pregnancy
Pregnancy Complications, Infectious* / immunology
SARS-CoV-2* / immunology
Spike Glycoprotein, Coronavirus / immunology

Substances

Antibodies, Viral
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2