Current Approaches to Prevent or Reverse Microbiome Dysbiosis in Chronic Inflammatory Rheumatic Diseases

Jan René Nkeck; Ange Larissa Tchuisseu-Kwangoua; Adeline Pelda; Wilson Chia Tamko; Saquinatou Hamadjoda; Doris Bibi Essama; Baudelaire Fojo; Moustapha Niasse; Saïdou Diallo; Madeleine Ngandeu-Singwé

doi:10.31138/mjr.240224.cap

Current Approaches to Prevent or Reverse Microbiome Dysbiosis in Chronic Inflammatory Rheumatic Diseases

Mediterr J Rheumatol. 2024 Jun 30;35(2):220-233. doi: 10.31138/mjr.240224.cap. eCollection 2024 Jun.

Authors

Jan René Nkeck^{1

2}, Ange Larissa Tchuisseu-Kwangoua^{1

3}, Adeline Pelda^{1

2

4}, Wilson Chia Tamko^{1

2

4}, Saquinatou Hamadjoda^{1

2

4}, Doris Bibi Essama², Baudelaire Fojo^{1

2

4}, Moustapha Niasse⁵, Saïdou Diallo⁵, Madeleine Ngandeu-Singwé^{1

2

4}

Affiliations

¹ Yaoundé Rheumatology Research Team, Yaoundé, Cameroon.
² Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
³ Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
⁴ Rheumatology Unit, Yaoundé Central Hospital, Yaoundé, Cameroon.
⁵ Department of Rheumatology, Dantec Teaching Hospital, Cheikh Anta Diop University, Dakar, Senegal.

Abstract

Advances in knowledge of the microbiome and its relationship with the immune system have led to a better understanding of the pathogenesis of chronic inflammatory rheumatic diseases (CIRD). Indeed, the microbiome dysbiosis now occupies a particular place with implications for the determinism and clinical expression of CIRD, as well as the therapeutic response of affected patients. Several approaches exist to limit the impact of the microbiome during CIRD. This review aimed to present current strategies to prevent or reverse microbiome dysbiosis based on existing knowledge, in order to provide practical information to healthcare professionals treating patients suffering from CIRD.

Keywords: chronic inflammatory rheumatic diseases; dysbiosis; microbiome; prevention; sub-Saharan Africa; treatment.

Publication types

Review