Interaction of Exosomal MicroRNA and Oxidative Stress in the Pathogenesis of Colitis-Associated Cancer

Front Biosci (Landmark Ed). 2024 Aug 7;29(8):276. doi: 10.31083/j.fbl2908276.

Abstract

Colitis-associated cancer (CAC) is the most serious complication of inflammatory bowel disease. In recent years, the incidence of CAC has increased worldwide. Oxidative stress (OS) is involved in the development of CAC through oxidative damage to biomolecules or activation of inflammatory signaling pathways. Exosomes are extracellular vesicles that act as messengers to deliver signals and macromolecules to target cells, making them important mediators of intercellular communication and exchange of biologically active molecules between cells. MicroRNAs (miRNAs) carried by exosomes regulate the pro- and anti-inflammatory pathways of OS and play a key role in communication between OS and cancer cells. This review describes the correlation between OS and exosomal miRNAs with the goal of identifying a novel therapeutic method for CAC.

Keywords: colitis-associated cancer; exosome microRNAs; oxidative stress.

Publication types

  • Review

MeSH terms

  • Animals
  • Colitis-Associated Neoplasms* / etiology
  • Colitis-Associated Neoplasms* / genetics
  • Colitis-Associated Neoplasms* / metabolism
  • Exosomes* / genetics
  • Exosomes* / metabolism
  • Humans
  • MicroRNAs* / genetics
  • MicroRNAs* / metabolism
  • Oxidative Stress*
  • Signal Transduction

Substances

  • MicroRNAs