Simultaneous Multiparameter Mapping of the Liver in a Single Breath-Hold or Respiratory-Triggered Acquisition Using Multi-Inversion Spin and Gradient Echo MRI

Mary Kate Manhard; Anandh Kilpattu Ramaniharan; Jean A Tkach; Andrew T Trout; Jonathan R Dillman; Amol S Pednekar

doi:10.1002/jmri.29584

Simultaneous Multiparameter Mapping of the Liver in a Single Breath-Hold or Respiratory-Triggered Acquisition Using Multi-Inversion Spin and Gradient Echo MRI

J Magn Reson Imaging. 2024 Aug 27. doi: 10.1002/jmri.29584. Online ahead of print.

Authors

Mary Kate Manhard^{1

2}, Anandh Kilpattu Ramaniharan¹, Jean A Tkach^{1

2}, Andrew T Trout^{1

2}, Jonathan R Dillman^{1

2}, Amol S Pednekar^{1

2}

Affiliations

¹ Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
² Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

PMID: 39192381
DOI: 10.1002/jmri.29584

Abstract

Background: Quantitative parametric mapping is an increasingly important tool for noninvasive assessment of chronic liver disease. Conventional parametric mapping techniques require multiple breath-held acquisitions and provide limited anatomic coverage.

Purpose: To investigate a multi-inversion spin and gradient echo (MI-SAGE) technique for simultaneous estimation of T₁, T₂, and T₂* of the liver.

Study type: Prospective.

Subjects: Sixteen research participants, both adult and pediatric (age 17.5 ± 4.6 years, eight male), with and without known liver disease (seven asymptomatic healthy controls, two fibrotic liver disease, five steatotic liver disease, and two fibrotic and steatotic liver disease).

Field strength/sequence: 1.5 T, single breath-hold and respiratory triggered MI-SAGE, breath-hold modified Look-Locker inversion recovery (MOLLI, T₁ mapping), breath-hold gradient and spin echo (GRASE, T₂ mapping), and multiple gradient echo (mGRE, T₂* mapping) sequences.

Assessment: Agreement between hepatic T₁, T₂, and T₂* estimated using MI-SAGE and conventional parametric mapping sequences was evaluated. Repeatability and reproducibility of MI-SAGE were evaluated using a same-session acquisition and second-session acquisition.

Statistical tests: Bland-Altman analysis with bias assessment and limits of agreement (LOA) and intraclass correlation coefficients (ICC).

Results: Hepatic T₁, T₂, and T₂* estimates obtained using the MI-SAGE technique had mean biases of 72 (LOA: -22 to 166) msec, -3 (LOA: -10 to 5) msec, and 2 (LOA: -5 to 8) msec (single breath-hold) and 36 (LOA: -43 to 120) msec, -3 (LOA: -17 to 11) msec, and 4 (LOA: -3 to 11) msec (respiratory triggered), respectively, in comparison to conventional acquisitions using MOLLI, GRASE, and mGRE. All MI-SAGE estimates had strong repeatability and reproducibility (ICC > 0.72).

Data conclusion: Hepatic T₁, T₂, and T₂* estimates obtained using an MI-SAGE technique were comparable to conventional methods, although there was a 12%/6% for breath-hold/respiratory triggered underestimation of T₁ values compared to MOLLI. Both respiratory triggered and breath-hold MI-SAGE parameter maps demonstrated strong repeatability and reproducibility.

Level of evidence: 1 TECHNICAL EFFICACY: Stage 2.

Keywords: free breathing; liver; quantitative MRI; rapid relaxometry.