Outcomes of Antiviral Retreatment for Immunocompromised Hosts With Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Polymerase Chain Reaction Positivity: A Multicenter Australian Retrospective Case Series

K A Bond; C Dendle; S Guy; M A Slavin; O Smibert; N Ibrahim; P M Kinsella; C O Morrissey; M A Moso; J J Sasadeusz

doi:10.1093/ofid/ofae449

Outcomes of Antiviral Retreatment for Immunocompromised Hosts With Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Polymerase Chain Reaction Positivity: A Multicenter Australian Retrospective Case Series

Open Forum Infect Dis. 2024 Aug 7;11(8):ofae449. doi: 10.1093/ofid/ofae449. eCollection 2024 Aug.

Authors

K A Bond^{1

2

3

4

5}, C Dendle^{6

7}, S Guy^{8

9}, M A Slavin^{4

5

10

11}, O Smibert^{4

12}, N Ibrahim⁶, P M Kinsella^{3

4

10}, C O Morrissey^{7

13}, M A Moso^{4

5}, J J Sasadeusz^{4

5}

Affiliations

¹ Department of Microbiology, Royal Melbourne Hospital, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
² Victorian Infectious Diseases Reference Laboratory, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
³ Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
⁴ Department of Infectious Diseases, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
⁵ Victorian Infectious Diseases Service, The Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
⁶ Department of Infectious Diseases, Monash Health, Melbourne, Victoria, Australia.
⁷ Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
⁸ Department of Infectious Diseases, Eastern Health, Melbourne, Victoria, Australia.
⁹ Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia.
¹⁰ Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
¹¹ Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
¹² Department of Infectious Diseases, Austin Health, Melbourne, Victoria, Australia.
¹³ Department of Infectious Diseases, Alfred Health, Melbourne, Victoria, Australia.

Abstract

Outcomes are presented for a multisite retrospective case series, describing a contemporary cohort of 22 immunocompromised patients with persistent coronavirus disease 2019 (COVID-19) polymerase chain reaction positivity who were retreated with antiviral therapy. For those with data available 14 and 30 days after commencement of antiviral therapy, 41% (9 of 22) and 68% (15 of 22), respectively, cleared COVID-19.