Disseminated fusariosis after allogenic hematopoietic stem cell transplantation: case report

A Gantner; J B Hagemann; B Grüner; G Walther; A Neagoie; V Wais; H Döhner; E Sala

doi:10.1007/s15010-024-02376-w

Disseminated fusariosis after allogenic hematopoietic stem cell transplantation: case report

Infection. 2024 Aug 26. doi: 10.1007/s15010-024-02376-w. Online ahead of print.

Authors

A Gantner¹, J B Hagemann², B Grüner³, G Walther⁴, A Neagoie³, V Wais³, H Döhner³, E Sala³

Affiliations

¹ Department of Internal Medicine III, University Hospital Ulm, Albert-Einstein-Allee 23, D-89081, Ulm, Germany. andrea.gantner@uniklinik-ulm.de.
² Institute of Medical Microbiology and Hygiene, University Hospital of Ulm, Albert-Einstein-Allee 23, D-89081, Ulm, Germany.
³ Department of Internal Medicine III, University Hospital Ulm, Albert-Einstein-Allee 23, D-89081, Ulm, Germany.
⁴ National Reference Center for Invasive Fungal Infections (NRZMyk), Leibniz Institute of Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany.

PMID: 39186217
DOI: 10.1007/s15010-024-02376-w

Abstract

In allogenic stem cell recipients, invasive fungal disease is a common yet dreaded complication with high mortality. Among these, fusariosis is especially complex to treat due to high intrinsic resistance and few antimycotic options, requiring close cooperation of all involved departments. We here report an instructive case of disseminated fusariosis after allogenic stem cell transplantation with fatal outcome despite maximum treatment.

Keywords: Allogenic hematopoietic stem cell transplantation; Fungal infection; Fusariosis; Fusarium.